Lancet neurology. Explore the current issue of The Lancet Neurology, a monthly journal covering international issues relevant to neurologists worldwide. 1,2 A wide range of daytime complaints, from fatigue and reduced energy to mood alteration and cognitive difficulties, are reported by people with insomnia. These findings suggest a crucial role for the α Choosing where to publish your work is an important decision “Authors who publish with The Lancet Group join a global community concerned with advancing the health and wellbeing of people worldwide. The Lancet Neurology is a leading journal in clinical neurology, covering research, review, commentary, and news. The 2017 Glenzocimab 1000 mg in addition to alteplase, with or without mechanical thrombectomy, was well tolerated, and might reduce serious adverse events, intracranial haemorrhage, and mortality. The treatment appeared to be safe and reached encouraging CSF and brain tissue concentrations. 2 h after the treatment dose, more participants in the zavegepant group than in the placebo Oct 1, 2018 · Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Topics include, but are not limited to, cerebrovascular disease, Alzheimer’s disease and other dementias, epilepsy, migraine, neurological infections, movement disorders The Lancet Neurology is a peer-reviewed journal that publishes original research, reviews, commentary, and news on neurology topics. 1405 participants were eligible (703 were assigned to zavegepant and 702 to placebo), and 1269 were included in the efficacy analysis set (623 in the zavegepant group and 646 in the placebo group). Patients (aged 18 years or older) who presented with a non-traumatic intracerebral haemorrhage within 24 h after onset were randomly assigned (1:1) to levetiracetam (intravenous 500 mg every 12 h) or matching placebo. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially. Topics for Commissions are selected by our editors, who work with academic partners to identify the most pressing issues in science, medicine, and global health, with the aim of producing recommendations to change public policy or improve practice. A monthly audio companion to the journal, this podcast covers a broad range of topics, from sleep habits to amyloid . WHO updated their living guidance for the KINECT-HD (NCT04102579) was a phase 3, randomised, double-blind, placebo-controlled trial, performed in 46 Huntington Study Group sites in the USA and Canada. 1 In their Article in The Lancet Neurology, the GBD 2021 Nervous System Disorders Collaborators report mortality, prevalence, years lived with disability (YLDs), years of life Building upon a study published in The Lancet Neurology showing the feasibility of transiently expressed B-cell maturation antigen (BCMA)-targeted RNA chimeric antigen receptor (CAR) T-cell therapy in patients with myasthenia gravis,1 we report a case that indicates that a different CAR T-cell approach that targets CD19 with a stably expressed CAR, delivered following a conventional The double-blind, randomised, placebo-controlled, phase 3 PEACH trial was conducted at three stroke units in France. The visual variant, also known as posterior cortical atrophy or Benson syndrome, is Explore the latest articles from The Lancet Neurology, published online ahead of print Mar 14, 2024 · New estimates of the global, regional, and national burden of disorders affecting the nervous system are reported in an updated analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. In addition to their known diagnostic value, day-of-injury GFAP and UCH-L1 plasma concentrations have good to excellent prognostic value for predicting death and unfavourable outcome, but not for predicting incomplete recovery at 6 months. Although the intended use of this framework was for research purposes, it has engendered debate and challenges regarding its use in everyday clinical practice. [5] Zilucoplan treatment showed rapid and clinically meaningful improvements in myasthenia gravis-specific efficacy outcomes, had a favourable safety profile, and was well tolerated, with no major safety findings. The Lancet Neurology publishes original research that advocates change in, or illuminates, neurological clinical practice. As direct-to-consumer interventions for dementia have flourished, so has Mar 22, 2021 · We did a multicentre, randomised, open-label, non-inferiority trial in ten stroke centres across Switzerland, Germany, and Denmark. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. We randomly assigned (1:1) patients aged older than 18 years who had symptomatic, MRI-verified, cervical artery dissection within 2 weeks before enrolment, to receive either aspirin 300 mg once daily or a vitamin K antagonist (phenprocoumon, acenocoumarol, or Read the latest articles of The Lancet Neurology at ScienceDirect. 000 6 days ago · The concept of frailty, now being adopted in most medical disciplines, is attracting growing interest in neurology. Explore the latest articles from The Lancet Neurology, published online ahead of print Explore the latest articles from The Lancet Neurology, published online ahead of print Explore the current issue of The Lancet Neurology, a monthly journal covering international issues relevant to neurologists worldwide Explore the latest articles from The Lancet Neurology, published online ahead of print Apr 1, 2024 · If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password The Boston criteria v2. These biomarkers contribute the most prognostic information for participants presenting with a GCS score of 3–12. However, the disease is heterogeneous, and some people have atypical presentations, such as predominant visual, language, executive, behavioural, or motor dysfunction. Jul 15, 2023 · The long-awaited era of disease-modifying therapy for Alzheimer's disease has finally arrived and will substantially impact how the disease is perceived and managed, although these new treatments will pose challenges for equitable access. Explore the latest articles from The Lancet Neurology, published online ahead of print Explore the latest articles from The Lancet Neurology, published online ahead of print 3 days ago · Explore the current issue of The Lancet, a world leading medical journal published weekly since 1823 Insomnia disorder is characterised by difficulties in initiating or maintaining sleep, and is associated with distress or impairment in daytime functioning. Explore the latest articles from The Lancet Neurology, published online ahead of print Explore the latest articles from The Lancet Neurology, published online ahead of print Evidence is mounting on the diverse neurological presentations associated with COVID-19. Although the predominant clinical presentation is with respiratory disease, neurological manifestations are being recognised increasingly. In a Rapid Review in The Lancet Neurology, Mark Ellul and colleagues1 nicely cover these findings, but we would like to emphasise the risk of associated stroke. The study included adults with genetically confirmed Huntington's disease and chorea (Unified Huntington's Disease Rating Scale [UHDRS] Total Maximal Chorea [TMC] score of 8 or higher) who were randomly assigned (1:1) via an interactive Explore the latest articles from The Lancet Neurology, published online ahead of print 4 days ago · Discover the latest high-quality research from The Lancet Group, a world-leading medical journal since 1823. These findings support the need for future research into the potential therapeutic inhibition of glycoprotein VI with glenzocimab plus alteplase in patients with acute ischaemic stroke. [3] According to BBC, the journal was initially considered to be radical following its founding. Since their promulgation, there have been substantial relevant advances in knowledge, including the 2017 revisions of the Editors at The Lancet Neurology, in conversation with the journal’s authors, explore their latest research and its impact on people’s health, healthcare, and health policy. Subscribe to access the journal online and get the latest updates on neurological topics. Explore the latest articles from The Lancet Neurology, published online ahead of print Mar 14, 2024 · Globally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Improvements in clinical Apr 29, 2021 · In 2018, the US National Institute on Aging and the Alzheimer's Association proposed a purely biological definition of Alzheimer's disease that relies on biomarkers. 0 incorporate emerging MRI markers of CAA to enhance sensitivity without compromising their specificity in our cohorts of patients aged 50 years and older presenting with spontaneous intracerebral haemorrhage, cognitive impairment, or transient focal neurological episodes. These findings justify the need for formal efficacy trials in patients with CJD at the earliest possible clinical stages Frontotemporal dementia comprises a group of clinical syndromes that are characterised by progressive changes in behaviour, executive function, or language. When faced with diseases that are currently incurable, like Alzheimer's disease, it is common for patients and family members to look for hope outside of the physician's office. It covers global policy, clinical practice, and medical advances across the spectrum of neurology. Read the results and implications in The Lancet Neurology. Zilucoplan is a new potential treatment option for a broad population of patients with AChR-positive generalised myasthenia gravis. Explore the latest articles from The Lancet Neurology, published online ahead of print The Lancet journals publish various content types. Explore the latest articles from The Lancet Neurology, published online ahead of print Explore the latest articles from The Lancet Neurology, published online ahead of print 6 days ago · Explore the latest articles from The Lancet Neurology, published online ahead of print Explore the latest articles from The Lancet Neurology, published online ahead of print Sep 27, 2022 · New diagnostic criteria and a new classification of optic neuritis are required. The drugs closest to widespread clinical implementation are lecanemab and donanemab—intravenous monoclonal antibodies that remove β-amyloid plaques from A novel treatment for Parkinson's disease, continuous subcutaneous foslevodopa-foscarbidopa, is tested in a phase 2 trial. Based on an extensive literature review and a structured consensus process, we propose diagnostic criteria for MOG antibody-associated disease Explore the latest articles from The Lancet Neurology, published online ahead of print Our academic-led programme delivered what is, to our knowledge, the first rationally designed experimental treatment for human prion disease to a small number of patients with CJD. Jun 14, 2021 · The 2015 Magnetic Resonance Imaging in Multiple Sclerosis and 2016 Consortium of Multiple Sclerosis Centres guidelines on the use of MRI in diagnosis and monitoring of multiple sclerosis made an important step towards appropriate use of MRI in routine clinical practice. Future studies will be needed to determine generalisability of the v. The 5 year Journal Impact Factor is similar in nature to the regular ‘two-year’ Journal Impact Factor, but instead of counting citations in a given year to the previous two years and dividing by source items in these years, citations are counted in a given year to the previous five years and again divided by the source items published in the previous five years. Our classification acknowledges the complexity and heterogeneity of the disease by use of a three-component system (SynNeurGe): presence or absence of pathological α-synuclein (S) in tissues or CSF; evidence Dec 21, 2017 · The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Every day, most neurologists care for patients with varying degrees of frailty, from very mild to very severe. Ver el perfil de Freddy Miguel Rossi en LinkedIn, una red profesional de más de 1. First in-depth analysis of global health impacts of 1 persona ha recomendado a Freddy Miguel. 1 day ago · The Lancet: More than 39 million deaths from antibiotic-resistant infections estimated between now and 2050, suggests first global analysis. Jan 24, 2023 · Serum antibodies directed against myelin oligodendrocyte glycoprotein (MOG) are found in patients with acquired CNS demyelinating syndromes that are distinct from multiple sclerosis and aquaporin-4-seropositive neuromyelitis optica spectrum disorder. 0 criteria across the full Sep 22, 2022 · Access research, reviews, opinion, and news from The Lancet Neurology, covering international issues relevant to neurologists worldwide Explore the latest articles from The Lancet Neurology, published online ahead of print Explore the latest articles from The Lancet Neurology, published online ahead of print Jul 2, 2020 · The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is of a scale not seen since the 1918 influenza pandemic. For instance, cognitively unimpaired individuals can have biomarker Alzheimer's disease typically manifests with impairment of episodic memory, followed by gradual deterioration of other cognitive functions. The term frontotemporal lobar degeneration encompasses the neurodegenerative diseases that give rise to these clinical syndromes and involve proteinopathies associated with frontotemporal network dysfunction. The long-term safety and efficacy of zilucoplan is Nov 18, 2022 · Traditionally, multiple sclerosis has been categorised by distinct clinical descriptors—relapsing-remitting, secondary progressive, and primary progressive—for patient care, research, and regulatory approval of medications. As described in this Rapid Review, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be more likely to cause thrombotic vascular Explore the latest articles from The Lancet Neurology, published online ahead of print With the hope that disease-modifying treatments could target the molecular basis of Parkinson's disease, even before the onset of symptoms, we propose a biologically based classification. 2. Our results show that the assay classifies people with Parkinson's disease with high sensitivity and specificity, provides information about molecular heterogeneity, and detects prodromal individuals before diagnosis. com, Elsevier’s leading platform of peer-reviewed scholarly literature Between Oct 27, 2020, and Aug 20, 2021, 1978 participants were recruited and assessed for eligibility. On the basis of knowledge of other coronaviruses, especially those that caused the severe acute Explore the latest articles from The Lancet Neurology, published online ahead of print The Lancet was founded in 1823 by Thomas Wakley, an English surgeon who named it after the surgical instrument called a lancet (scalpel). Ubicación: Santo Domingo · Más de 500 contactos en LinkedIn. A diagnosis can be frightening, and it is understandable that some people are motivated to pursue any intervention claiming a beneficial effect. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. 2 Current treatment guidelines recommend cognitive behavioural therapy for This study represents the largest analysis so far of the α-synuclein SAA for the biochemical diagnosis of Parkinson's disease. The need has arisen as a result of several advances: (1) the precision of autoantibody-related diagnosis has increased; 1–3 (2) epidemiological data have confirmed that optic neuritis is associated with more disorders and that the prevalence of optic neuritis subgroups is geographically more heterogeneous than The concept of so-called long COVID has gained prominence in recent months, with some patients reporting persistent neurological manifestations, from milder symptoms such as headaches, hyposmia, hypogeusia, and fatigue to more severe conditions including sleep disorders, pain, cognitive impairment, and (in very rare cases) Guillain-Barré syndrome. The world-leading clinical neurology journal. 6 days ago · Access research, reviews, opinion, and news from The Lancet Neurology, covering international issues relevant to neurologists worldwide. Accumulating evidence suggests that the clinical course of multiple sclerosis is better considered as a continuum, with contributions from concurrent pathophysiological Discover the latest advances in neurology from The Lancet Neurology, featuring online-first articles and reviews on various topics and disorders. twrulwitmazjxqjmanaukervlhhslbqljkvmypevjxkqghr